Wednesday, August 22, 2012

Carisoprodol is likely to be more regulated soon

There is a long history to this drug, it being approved by the FDA in 1959 before the current requirements for clinical trials were introduced. By 2000, it had become the second most commonly prescribed muscle relaxant. In 2006, more than 10 million prescriptions were written. This would suggest the drug is well-regarded by doctors and used under their supervision in hospitals and other clinical surroundings. But this is not the case. Because it is freely available as a generic drug and so cheap, it is rapidly becoming a drug of abuse and sixteen US states have now reclassified it as a schedule IV controlled substance. This is potentially a dangerous development because, unlike other drugs which have been abused for decades, there are no medical protocols in place for dealing with addiction and the inevitable withdrawal systems. Why has it taken so long for the level of abuse to rise? In part, it is because the effect of the drug is as a tranquilizer or sedative at higher dosages. Fifty years ago, people preferred their recreation to involve excitement rather than sleep. Indeed, if you look at the information given out by the manufacturer today, you will see drowsiness given as a common side effect.
Even after all these years, there is still no medical explanation of how Carisoprodol achieves its effect. Indeed, despite increasingly frequent reports of addiction from 1978 onwards, doctors cannot explain why patients become dependent. Given this uncertainty, it should not be surprising that Carisoprodol has now been listed as a drug of concern by the Department of Justice Drug Enforcement Agency. The DEA's interest at a federal level comes from recent evidence that large quantities of the drug are being diverted from wholesale to street distribution. In 2007, the World Health Organization announced its opinion that the abuse potential now outweighed any possible medical benefit from its use unless patients could be persuaded only to use it for very short periods of time. You may therefore expect the supply of this drug to become more tightly controlled within the US. Whether the same happens to the international pharmacies will depend on where they are based. However, you should be aware that there may be increased customs inspections as the drugs come into the country. Access to the chemistry of escape may soon be limited.